Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT

CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA

CRYSTAL STRUCTURES OF PROTEIN KINASE B SELECTIVE INHIBITORSIN COMPLEX WITH PROTEIN KINASE A AND MUTANTS

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTICSUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR1-(5- ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID ( 2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL) AMIDE

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH (4R,2S)-5'-(4-(4- CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL) ISOQUINOLINE

PKA COMPLEXED WITH (S)-2-(1H-INDOL-3-YL )-1-(5-ISOQUINOLIN-6-YL-PYRIDIN-3- YLOXYMETHYL-ETYLAMINE

PKA FIVEFOLD MUTANT MODEL OF RHO-KINASE WITH INHIBITORFASUDIL (HA1077)

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A-443654

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4- CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH A-443654

MODEL STRUCTURE OF THE CATALYTIC SUBUNIT- REGULATORY SUBUNITDIMERIC COMPLEX OF THE CAMP -DEPENDENT PROTEIN KINASE

MODEL STRUCTURE OF THE CATALYTIC SUBUNIT- REGULATORY SUBUNITDIMERIC COMPLEX OF THE C- AMP-DEPENDENT PROTEIN KINASE

PKA DOUBLE MUTANT MODEL OF PKB IN COMPLEX WITH MGATP

THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE(PKA) IN COMPLEX WITH RHO- KINASE INHIBITOR Y-27632

THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE INCOMPLEX WITH RHO-KINASE INHIBITOR H-1152P

THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE INCOMPLEX WITH RHO-KINASE INHIBITOR FASUDIL (HA-1077)

PROTEIN KINASE A VARIANT COMPLEX WITH COMPLETELY ORDERED N-TERMINAL HELIX

CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT INCOMPLEX WITH STAUROSPORINE

CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITHAZEPANE DERIVATIVE 1

CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITHAZEPANE DERIVATIVE 4

CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITHAZEPANE DERIVATIVE 8

DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEINKINASE A (PKA)

CRYSTAL STRUCTURE OF PROTEIN KINASE A IN COMPLEX WITHAZEPANE DERIVATIVE 5

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTICSUBUNIT IN COMPLEX WITH H8 PROTEIN KINASE INHIBITOR[N-(2-METHYLAMINO) ETHYL]-5-ISOQUINOLINESULFONAMIDE

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTICSUBUNIT IN COMPLEX WITH H89 PROTEIN KINASE INHIBITORN-[2-(4- BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE

CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITHPKI-5-24

PROTEIN KINASE A FIVEFOLD MUTANT MODEL OF RHO-KINASE WITH Y-27632

PROTEIN KINASE A FIVEFOLD MUTANT MODEL OF RHO-KINASE

PKA FIVE FOLD MUTANT MODEL OF RHO-KINASE WITH H1152P

PKA THREE FOLD MUTANT MODEL OF RHO-KINASE WITH Y-27632

PKA THREEFOLD MUTANT MODEL OF RHO-KINASE WITH INHIBITOR H-1152P

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 7-AZAINDOLE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-PHENYL-C-(4-(9H-PURIN-6-YL)-PHENYL )-METHYLAMINE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4- YL)-PHENYL)-9H-PURINE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 2-(4-(5-METHYL-1H-PYRAZOL-4-YL)-PHENYL )-ETHYLAMINE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (R)-2-(4-CHLORO-PHENYL)-2-(4-1H- PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (S)-2-(4-CHLORO-PHENYL)-2-(4-1H- PYRAZOL-4-YL)-PHENYL)-ETHYLAMINE

ENGINEERED RESIDUE IN CHAIN A, VAL 104 TO THR ENGINEERED RESIDUE IN CHAIN A, VAL 123 TO ALA ENGINEERED RESIDUE IN CHAIN A, LEU 173 TO MET ENGINEERED RESIDUE IN CHAIN A, GLN 181 TO LYS
4 RESIDUES OF THE WILD-TYPE PKA SEQUENCE HAVE BEEN MUTATED TO THE CORRESPONDING RESIDUES IN PKB

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT (E.C.2.7.11.11), CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA

TRANSFERASE/INHIBITOR, CAMP, KINASE, MYRISTATE, TRANSFERASE, LIPOPROTEIN, SERINE/THREONINE-PROTEIN KINASE, NUCLEOTIDE-BINDING, PROTEIN KINASE INHIBITOR, ATP-BINDING, NUCLEAR PROTEIN, PHOSPHORYLATION, TRANSFERASE-INHIBITOR COMPLEX