Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation

1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.

MHC class I antigen,MHC class I histocompatibility antigen

12.5% PEG 4000, 0.1M Na Cacodylate pH 5.8, 0.2M (NH4)2SO4 and 10% glycerol

TCR-V-alpha-12-02*01, TCR-V-beta-10-2*01, HLA class I antigen, Beta-2-microglobulin, GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU