Y271G DNA polymerase beta substrate complex with a templating cytosine and incoming rGTP

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta.

DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3')

19% PEG3350, 0.35 M sodium acetate, 0.05 M Imidazole, pH 8.0.

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

DNA polymerase, ribonucleotide, oxidized nucleotide, DNA damage, DNA BINDING PROTEIN, TRANSFERASE-DNA complex