Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-Methyl-7-[3-((methylamino)methyl)phenethyl]quinolin-2-amine

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Residues 339 to 349 are disordered.
The N-terminal residues 297 and 298
as well as C-terminal residues 717
and 718 are not observed in density

BNOS,Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1

20-24% PEG3350, 0.1M MES,0.14-0.20M AMMONIUM ACETATE, 10% ETHYLENE GLYCOL, 30uM SDS, 5 mM GSH

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

reflection file was treated with the diffraction anisotropy correction

Nitric oxide synthase, brain (E.C.1.14.13.39)

nitric oxide synthase, inhibitor complex, heme enzyme, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex