Clostridium difficile TcdA-CROPs bound to PA50 Fab

Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.

0.1 M Tris pH 7.5
0.6 M calcium chloride
19% PEG 3350

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

chain 'C' and (resid 2461 through 2493 )

chain 'C' and (resid 2494 through 2573 )

chain 'C' and (resid 2574 through 2687 )

chain 'C' and (resid 2688 through 2705 )

Toxin A (E.C.3.4.22.-), PA50 Fab Light chain, PA50 Fab Heavy chain

toxin antibody, TOXIN-IMMUNE SYSTEM complex