Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3573

Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

1-(5-ETHOXYPYRIDIN-3-YL)-1,4-DIAZEPANE (NS3573) BINDS AT THE INTERFACE OF EACH TWO MONOMERS

0.1 M TRIS BASE (PH 8.0), 1-3% V/V POLYETHYLENE GLYCOL (PEG) 400 AND 1.8-2.3 M (NH4)2SO4

ENGINEERED LS-ACHBP WITH ALPHA4-ALPHA4 INTERFACE IN COMPLEX WITH NS3920

SIGNALING PROTEIN, ION CHANNEL, RECEPTOR STOICHIOMETRY, CYS-LOOP RECEPTOR, ACETYLCHOLINE BINDING PROTEIN