Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine in complex with the viral receptor BARF1

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

CSF-1, M-CSF, MCSF, Lanimostim, Processed macrophage colony-stimulating factor 1

0.1M Tris HCl, 1.0M ammonium sulphate, pH 8.50, VAPOR DIFFUSION, SITTING DROP, temperature 293K

Secreted protein BARF1, Macrophage colony-stimulating factor 1

VIRAL RECEPTOR, RTKIII, EXTRACELLULAR, CYTOKINE RECEPTOR-CYTOKINE complex, CYTOKINE, FOUR-HELIX BUNDLE, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, ONCOGENE, RECEPTOR, CYTOKINE/SIGNALING, PROTEIN COMPLEX