Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP

How a DNA polymerase clamp loader opens a sliding clamp.

Clamp loader large subunit, Protein Gp44

Clamp loader small subunit, Protein Gp62

DNA polymerase accessory protein 45, Gp45

10% PEG4k, 0.1M MES pH 6.5, 20mM NaCl, 10mM MgCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K

DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, DNA polymerase processivity component/DNA complex

AAA+, ATP hydrolase, clamp loader, sliding clamp, primer-template DNA, DNA BINDING PROTEIN-DNA complex