CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.

Activin receptor type IIA,ACTR-IIA,ACTRIIA

Activin beta-A chain,Erythroid differentiation protein,EDF

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Cell Signaling, Receptor-ligand complex, Growth factor, Receptor interaction, Activin A, ActRIIa, SIGNALING PROTEIN

(chain A and (resid 27 through 55 or (resid 56 and (name N or name CA or name C or name O or name CB )) or resid 57 through 120 or resid 20 through 21))

(chain C and (resid 27 through 66 or (resid 67 and (name N or name CA or name C or name O or name CB )) or resid 68 through 94 or (resid 95 through 96 and (name N or name CA or name C or name O or name CB )) or resid 97 through 120 or resid 20 through 21))

(chain E and (resid 27 through 54 or (resid 55 through 56 and (name N or name CA or name C or name O or name CB )) or resid 57 through 66 or (resid 67 and (name N or name CA or name C or name O or name CB )) or resid 68 through 94 or (resid 95 through 96 and (name N or name CA or name C or name O or name CB )) or resid 97 through 116 or (resid 117 and (name N or name CA or name C or name O or name CB )) or resid 118 through 120 or resid 20 through 21))

(chain G and (resid 27 through 54 or (resid 55 through 56 and (name N or name CA or name C or name O or name CB )) or resid 57 through 66 or (resid 67 and (name N or name CA or name C or name O or name CB )) or resid 68 through 94 or (resid 95 through 96 and (name N or name CA or name C or name O or name CB )) or resid 97 through 116 or (resid 117 and (name N or name CA or name C or name O or name CB )) or resid 118 through 120 or resid 20 through 21))

(chain B and (resid 311 or (resid 312 through 313 and (name N or name CA or name C or name O or name CB )) or resid 314 through 324 or (resid 325 and (name N or name CA or name C or name O or name CB )) or resid 326 through 352 or (resid 353 and (name N or name CA or name C or name O or name CB )) or resid 354 through 361 or resid 367 through 378 or (resid 379 and (name N or name CA or name C or name O or name CB )) or resid 380 or (resid 381 and (name N or name CA or name C or name O or name CB )) or resid 382 through 383 or resid 385 or (resid 388 and (name N or name CA or name C or name O or name CB )) or resid 389 through 407 or (resid 408 and (name N or name CA or name C or name O or name CB )) or resid 409 through 426))

(chain D and (resid 311 or (resid 312 through 313 and (name N or name CA or name C or name O or name CB )) or resid 314 through 324 or (resid 325 and (name N or name CA or name C or name O or name CB )) or resid 326 through 352 or (resid 353 and (name N or name CA or name C or name O or name CB )) or resid 354 through 364 or resid 367 through 376 or (resid 377 through 379 and (name N or name CA or name C or name O or name CB )) or resid 380 or (resid 381 and (name N or name CA or name C or name O or name CB )) or resid 382 through 383 or resid 385 or resid 388 through 426))

(chain F and (resid 311 or (resid 312 through 313 and (name N or name CA or name C or name O or name CB )) or resid 314 through 318 or (resid 319 and (name N or name CA or name C or name O or name CB )) or resid 320 through 376 or (resid 377 through 379 and (name N or name CA or name C or name O or name CB )) or resid 380 or (resid 381 and (name N or name CA or name C or name O or name CB )) or resid 382 through 383 or resid 385 or resid 388 through 407 or (resid 408 and (name N or name CA or name C or name O or name CB )) or resid 409 through 426))

(chain H and ((resid 311 through 313 and (name N or name CA or name C or name O or name CB )) or resid 314 through 316 or (resid 317 and (name N or name CA or name C or name O or name CB )) or resid 318 or (resid 319 and (name N or name CA or name C or name O or name CB )) or resid 320 through 324 or (resid 325 and (name N or name CA or name C or name O or name CB )) or resid 326 through 352 or (resid 353 and (name N or name CA or name C or name O or name CB )) or resid 354 through 376 or (resid 377 through 379 and (name N or name CA or name C or name O or name CB )) or resid 380 through 394 or (resid 395 and (name N or name CA or name C or name O or name CB )) or resid 396 through 407 or (resid 408 and (name N or name CA or name C or name O or name CB )) or resid 409 through 426))