Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.

Residues ASN C 544 and GLY C 545 that are next to each other in the sample sequence are not properly linked: distance between C and N is 3.26.

Residues PHE C 643 and GLN C 644 that are next to each other in the sample sequence are not properly linked: distance between C and N is 3.03.

Residues PHE E 643 and GLN E 644 that are next to each other in the sample sequence are not properly linked: distance between C and N is 3.02.

FSR22, a trimer of three DARPin molecules formed by foldon at its N-terminus
DARPin FSR22 in complex with SARS-CoV-2 spike

Severe acute respiratory syndrome coronavirus 2

Escherichia phage EcSzw-2Escherichia coli

National Institutes of Health/National Cancer Institute (NIH/NCI)

DARPins, Anti-SARS-CoV-2, therapeutics, COVID-19, VIRAL PROTEIN-ANTIVIRAL PROTEIN complex