Crystal structure of S. aureus FabI in complex with NADPH and kalimantacin B

(2~{E},5~{R},10~{E},12~{E},15~{S},19~{R})-20-[[(2~{R},3~{R})-3-aminocarbonyloxy-2-methyl-butanoyl]amino]-3,5,15-trimethyl-7-methylidene-19-oxidanyl-17-oxidanylidene-icosa-2,10,12-trienoic acid

NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.

Enoyl-[acyl-carrier-protein] reductase [NADPH]

0.2 M NaCl, 0.1 M Na/K phosphate pH 6.2, 20% (w/v) PEG 1000

Engineering and Physical Sciences Research Council

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

Enoyl-[acyl-carrier-protein] reductase [NADPH] (E.C.1.3.1.39)

enoyl-[acyl carrier protein] reductase, fatty acid biosynthesis, Rossmann fold, short-chain dehydrogenase/reductase, BIOSYNTHETIC PROTEIN