Structure of SARS-CoV-2 3CL protease in complex with inhibitor 7c

(1S,2S)-2-{[N-({[7-(tert-butoxycarbonyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid

Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease.

3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase

Severe acute respiratory syndrome coronavirus 2

20% (w/v) PEG 3350, 200 mM sodium fluoride

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

COVID-19, PROTEASE, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 3CL protease Inhhibitors, hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex