Crystal structure of CYP124 in complex with vitamin D3

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLI DENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL

Metabolic Fate of Human Immunoactive Sterols in Mycobacterium tuberculosis.

Cholest-4-en-3-one C26-monooxygenase,Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming],Cholesterol C26-monooxygenase,Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming],Cytochrome P450 124,Steroid C26-monooxygenase,Steroid C27-monooxygenase

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

25% PEG 3350, 0.1M BisTris, 0.2M Magnesium chloride

Methyl-branched lipid omega-hydroxylase (E.C.1.14.15.14,1.14.15.28)

Cytochrome, P450, CYP, OXIDOREDUCTASE, vitaminD3, D3, vitamin, 124, CYP124, cholecalciferol, calciferol, tuberculosis, mycobacterium tuberculosis