Crystal Structure of PI3Kalpha in complex with fragments 19 and 28

Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Phosphatidylinositol 3-kinase regulatory subunit alpha

PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA

PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha

National Institutes of Health/National Cancer Institute (NIH/NCI)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (E.C.2.7.1.153,2.7.11.1), Phosphatidylinositol 3-kinase regulatory subunit alpha

lipid kinase, phosphoinositide, 3-kinase, signaling, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex