Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map

Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.

double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex

Ubiquitin-like modifier-activating enzyme 7

Ubiquitin/ISG15-conjugating enzyme E2 L6

Ubiquitin-activating enzyme 7,D8,Ubiquitin-activating enzyme E1 homolog

Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP

E2 ubiquitin-conjugating enzyme L6,Retinoic acid-induced gene B protein,RIG-B,UbcH8,Ubiquitin carrier protein L6,Ubiquitin-protein ligase L6

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Complex, ubiquitin, ligase, SIGNALING PROTEIN