Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GalNAc

(2R,3R,4R,5R,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate

Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1

0.1 M Bis tris propane pH 8.75, 0.2 M Potassium sodium tartrate, 20 % PEG3350

German Federal Ministry for Education and Research

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (E.C.2.6.1.16)

Glutamine fructose-6-phosphate aminotransferase, GFAT, Ntn hydrolase, TRANSFERASE