Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor

Exploring Novel HIV-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise.

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

50 mM MES pH 6.0, 16% PEG 8000, 100 mM ammonium sulfate, 15 mM magnesium sulfate, and 5 mM spermine

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

REVERSE TRANSCRIPTASE, ANTIVIRAL, DRUG DESIGN, HIV-1, VIRAL PROTEIN, Hydrolase