Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation

Synergistic activation of the insulin receptor via two distinct sites.

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)

insulin receptor, site 1 binding deficient mutant insulin, SIGNALING PROTEIN, SIGNALING PROTEIN-HORMONE complex