Cryo-EM structure of human ACKR3 in complex with a small molecule partial agonist CCX662, and an intracellular Fab

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.

Complex structure of ACKR3-CCX662-
CID24

C-X-C chemokine receptor type 7,CXC-R7,CXCR-7,Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog,RDC-1

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

National Institutes of Health/National Cancer Institute (NIH/NCI)

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Cryo-EM structure of ACKR3 in complex with a small molecule agonist, and an intracellular Fab.

Atypical Chemokine Receptor, MEMBRANE PROTEIN, SIGNALING PROTEIN, SIGNALING PROTEIN-IMMUNE SYSTEM complex