Crystal Structure of human phosphodiesterase 10 in complex with 7-methyl-2,5-bis[2-(1-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine

Crystal Structure of a human phosphodiesterase 10 complex

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

5-20 mg/mL protein in 25mM HEPES/NaOH pH7.5, 150mM NaCl, 50mM BME mixed 1:1 with reservoir 0.1M HEPES/NaOH pH7.5, 30% PEG550MME, 50mM MgCl2

5-Cyclopentyl-1-methyl-1H-[1,2,4]triazol-3-yl connected to triazolopyrimidine core may be rotated 180deg as was built for molecule A and is less well defined by electron density as the same group in the glycine pocket.

PHOSPHODIESTERASE, PDE10, HYDROLASE, SCHIZOPHRENIA, HYDROLASE-HYDROLASE inhibitor complex