Mycobacterium tuberculosis alanine racemase inhibited by DCS

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

N-terminal GSH is part of the thrombin recognition site

100 mM sodium MES buffer pH 6.2, 150 mM CaCl, 10% (v/v) PEG Smear Broad, 3% (v/v) Glycerol

Medical Research Council (MRC, United Kingdom)

The homodimer represents the Biological assembly. The enzyme is only active as a dimer.

Enzyme, alanine racemase, peptidoglycan biosynthesis, ISOMERASE