Crystal structure of a Aar2-Prp8 complex

Mechanism for Aar2p function as a U5 snRNP assembly factor.

Yeast Prp8p RNaseH like domain, residues 1836-2092

DBF3, DNA39, PRP8, RNA8, SLT21, USA2, YHR165C

0.1 M Tris-HCl, pH 8.5, 0.1 M lithium sulfate, 20 % PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 277K

Pre-mRNA-splicing factor 8, A1 cistron-splicing factor AAR2

RNaseH like domain, VHS like domain, U5 snRNP assembly, SPLICING