Human PARP1 deltaV687-E688 bound to a DNA double strand break.

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery.

Fusion of human PARP1 zinc fingers 1 and 3 (Zn1, Zn3)

PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,DNA ADP-ribosyltransferase PARP1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1,Protein poly-ADP-ribosyltransferase PARP1

Canadian Institutes of Health Research (CIHR)

PARP, ADP-ribose transferase, DNA break detection, zinc finger, DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex

(chain A and (resid 6 through 400 or resid 500))

(chain C and (resid 6 through 91 or resid 227 through 400 or resid 500))

(chain B and (resid 531 through 646 or resid 663 or resid 665 through 689 or resid 691 through 1020 or resid 1101))

(chain D and (resid 531 through 646 or resid 663 or resid 665 through 689 or resid 691 through 780 or resid 787 through 1020 or resid 1101))