The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1

0.1 M lithium sulfate monohydrate, 0.1M sodium citrate tribasic dihydrate, and 20% w/v polyethylene glycol 1000 , pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 295K

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (E.C.3.1.5.-)

HD-domain, hydrolase, dNTP and GTP binding, phosphorylation