Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.

DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*TP*CP*TP*TP*TP*GP*AP*TP*GP*G)-3')

8% PEG1000, 0.1 M KCl, 10 mM MgCl2, 0.1 M MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Interferon-inducible protein AIM2/DNA complex

CYTOSOLIC DNA SENSOR, INFLAMMASOME, DNA BINDING, CYTOSOLIC, Immune system-DNA complex