Crystal structure of PHGDH in complex with compound 15

4-[(1~{R})-1-[(2-methyl-5-phenyl-pyrazol-3-yl)carbonylamino]ethyl]benzoic acid

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.

3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase

25 % PEG 8000, 0.1 M MES, 0.2 M Lithium sulphate

Protein-Ligand complex, Dehydrogenase, OXIDOREDUCTASE