Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

[2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]{2-[(2-oxoethyl)(2-phosphonoethyl)amino]ethyl}amino)ethyl]phosphonic acid

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.

Hypoxanthine-guanine phosphoribosyltransferase

20% PEG8000, 0.1M Tris-HCl pH8.5, 0.2M MgCl2, VAPOR DIFFUSION, HANGING DROP, temperature 291K

This sequence occurs naturally in Mycobacterium tuberculosis

6-oxopurine phosphoribosyltransferase, Cytoplasmic, transferase-transferase inhibitor complex