Crystal structure of the ADCC-Potent Antibody N60-I3 Fab in complex with HIV-1 Clade A/E gp120 and M48u1

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.

FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY N60-i3

FAB LIGHT CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY N60-i3

10-16% PEG 8000, 0.1 M Tris-HCl pH 8.5, 65 mM NaCl, VAPOR DIFFUSION, HANGING DROP, temperature 294K

Crystal structure of the ADCC potent antibody n5-i5 Fab, HIV-1 gp120, and soluble two domain CD4

Crystal structure of the ADCC potent Rhesus macaque antibody JR4, HIV-1 gp120, and the M48 CD4 mimetic

Crystal structure of the YU2 gp120 and the M48u1 CD4 mimetic

THE CD4-MIMETIC MINIPROTEINS INHIBIT HIV-1 ENTRY AND ARE DERIVED FROM SCYLLATOXIN (A SCORPION TOXIN) BY TRANSPLANTING THE GP120-INTERACTIVE REGION OF CD4 ONTO THE SCYLLATOXIN SCAFFOLD, FOLLOWED BY MANY ROUNDS OF ITERATIVE OPTIMIZATION

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
PDB ENTRY 3TNN FOR N60-I3, PDB ENTRY 4H8W FOR GP120, PDB ENTRY 4JZW FOR M48U1

HIV-1 clade A/E gp120, m48u1 CD4 mimetic peptide, N60-i3 Fab heavy chain, N60-i3 Fab light chain

HIV-1 GP120, CLADE A/E 93TH057, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM-INHIBITOR complex