Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

20% PEG3350, 200 mM Na2SO4, 100 mM Bis-Tris propane, pH 7.5, vapor diffusion, hanging drop, temperature 293K

kinase domain, inhibition, dimer, Alternative splicing, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Ubl conjugation, Cytoplasm