Structural Studies of Streptococcus pneumoniae EPSP Synthase, Tetrahedral intermediate Bound State

(3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID

Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.

5-enolpyruvylshikimate-3-phosphate synthase

PEG, EG, NaCl, Na/K phosphate, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K

HETEROGEN
SPQ IS THE FLUORINATED TETRAHEDRAL INTERMEDIATE.

5-enolpyruvylshikimate-3-phosphate synthase (E.C.2.5.1.19)

shikimate pathway, EPSP synthase, S3P, Glyphosate, PEP, S. pneumoniae, TRANSFERASE