Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.

100MM TRIS, 200MM LITHIUM SULFATE, 22% PEG 3,350, PH 8.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K

AUTHORS STATE THAT THE SEQUENCE IN THIS STUDY HAS BEEN CONFIRMED BY CDNA SEQUENCING

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

ALPHA-HELICES, ISOPRENE BIOSYNTHESIS, TRANSFERASE-TRANSFERASE INHIBITOR complex