Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form

Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

0.1 M HEPES pH 7.0, 28-30% Jeffamine ED 2001 pH 7.0, vapor diffusion, hanging drop, temperature 294K

AADC in the open conformation with LLP and PLP bound to Chain-A and Chain-B respectively

Aromatic-L-amino-acid decarboxylase (E.C.4.1.1.28)

apo enzyme, apo form, open conformation, open dimer, exposed, conformational change, Parkinson, AADC deficiency, DDC, Decarboxylase, PLP binding, LYASE