J22.9-H, fully humanized Fab Fragment based on chimeric J22.9-xi IgG against BCMA

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Structure-based humanization of a therapeutic antibody for Multiple Myeloma

Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.

Extracellular domain of BCMA (B-cell maturation antigen, CD269)

14% PEG 3350
100 mM BisTris
7.5 mM Cu(II)

Fab fragment, humanized, BCMA binding, IMMUNE SYSTEM