Crystal structure of human Mcl-1 in complex with compound 1

4-O-BETA-METHYL-D-GLUCOPYRANOSYL CELLOBIONOLACTAM OXIME

Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.

MBP-MCL1 fusion protein as in PDB entry 4WGI. The construct contains (N-terminus to C-terminus): (1) a Gly residue; (2) residues K27-T392 of E. coli malE (P0AEY0); (3) a Gly-Ser linker; (4) residues E173-V321 of H. sapiens MCL1 (Q07820) and the mutations K194A, K197A and R201A,MBP-MCL1 fusion protein as in PDB entry 4WGI. The construct contains (N-terminus to C-terminus): (1) a Gly residue; (2) residues K27-T392 of E. coli malE (P0AEY0); (3) a Gly-Ser linker; (4) residues E173-V321 of H. sapiens MCL1 (Q07820) and the mutations K194A, K197A and R201A
Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1

MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT

Hydrogens have been added in their riding positions