STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.

Structure of the complex between human T-cell receptor, viral peptide and HLA-A

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.

seeding with hanging drop vapor diffusion; 50 mM MOPS, pH 7.0, 75 mM MgSO4 and 13% PEG 8000, VAPOR DIFFUSION, HANGING DROP, temperature 290K

1AO7 contains the same human A6-TCR and the same human MHC HLA-A2. In 1AO7 the sequence of HTLV-1 Tax peptide is LLFGYPVYV. In the current entry, the Valine residue at position 7 on Tax is mutated to an Arginine.

R-free set was selelcted as the same set used in Garboczi et al., Nature (1996)

HUMAN T CELL RECEPTOR, TCR-PEPTIDE-MHC COMPLEX, HLA-A2, IMMUNE SYSTEM