Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 14 (Methyl 2-aminopyridine-4-carboxylate)

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.

M1G-methyltransferase,tRNA [GM37] methyltransferase

0.08M Sodium cacodylate pH 6.5 -7.0, 1-2 M Ammonium sulphate

Cystic Fibrosis Trust Registered Charity No. (England and Wales) 1079049, Registered Charity No. (Scotland) SC040196

tRNA (guanine-N(1)-)-methyltransferase (E.C.2.1.1.228)

TrmD, tRNA methyltransferase, SPOUT methyltransferase, TRANSFERASE