Crystal Structure of seryl-tRNA synthetase from Candida albicans

Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.

Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase from Candida albicans.

Serine--tRNA ligase, SerRS, Seryl-tRNA(Ser/Sec) synthetase

3.2-3.4 M ammonium sulfate, 0-2% v/v glycerol, 100 mM MES/sodium, pH 5.6-5.8, VAPOR DIFFUSION, temperature 298K

Apo-enzyme (major isoform: CUG codon translated as a serine)

Apo-enzyme (minor isoform: CUG codon translated as a leucine)

Complex with ATP (major isoform: CUG codon translated as a serine)

Seryl-tRNA synthetase, cytoplasmic (E.C.6.1.1.11)

class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily, Aminoacyl-tRNA synthetase, serine, tRNA, LIGASE