THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 6

4'-((2S)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)-1,1'-BIPHENYL-3-YLPHOSPHONIC ACID

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B

Protein-tyrosine phosphatase, non-receptor type 1

PEG 3350, MGCL2, HEPES, pH 7.00, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Same protein in complex with [4-(2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl)phenyl](difluoro)methylphosphonic acid

Same protein in complex with {[2-(1H-1,2,3-benzotriazol-1-yl)-2-(3,4-difluorophenyl)propane-1,3-diyl]bis[4,1-phenylene(difluoromethylene)]}bisphosphonic acid

Same protein in complex with [{4-[(4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-1,2,3-benzotriazol-1-yl)-5-phenylpent-4-en-1-yl]phenyl}(difluoro)methyl]phosphonic acid

Same protein in complex with {6-[4-(2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl)phenyl]-2-methylquinolin-8-yl}phosphonic acid

Same protein in complex with [6-[4-(2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl)phenyl]-2-(1-methoxy-3-methylbutyl)quinolin-8-yl]phosphonic acid

PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)

PHOSPHATASE, SECONDARY BINDING SITE, SELECTIVITY, HYDROLASE