Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5

Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development.

GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2

14-15% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 3.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 6.5

IN THIS PROTEIN PART OF THE TRANSMEMBRANE ION CHANNEL HAS BEEN REMOVED AND REPLACED BY A GT LINKER

glutamate receptor, GluA2, GluR2, AMPA receptor, LBD, neurotransmitter receptor, nitrowillardiine, TRANSPORT PROTEIN