Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2.

Acta Crystallogr., Sect. D: Biol. Crystallogr.
Towards automated crystallographic structure refinement with phenix.refine.

7.5%(W/V) PEG 8K, 0.1 M Bis-tris pH 6.3, 0.2 M MgCl2

European Communitys Seventh Framework Programme

Epigenetics, Trypanosoma cruzi, Histone deacetylase, DAC2, Pathogen, Hydrolase