Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

Structure-Guided Development of Selective RabGGTase Inhibitors.

Residues 1-237 and 353-441 were linked by a four residues linker AGSG.
Geranylgeranyl transferase type-2 subunit alpha

Geranylgeranyl transferase type-2 subunit beta

Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha, Rab geranylgeranyltransferase subunit alpha

Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta

coexpression of engineered alpha-subunit from pGATEV and beta-subunit from pET3 0a

14% (w/v) PEG3350, 0.2 M Ca(OAc)2, 0.1 M HEPES, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 284K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Geranylgeranyl transferase type-2 subunit alpha (E.C.2.5.1.60), Geranylgeranyl transferase type-2 subunit beta (E.C.2.5.1.60)

protein prenylation, fusion protein, chimera protein, TRANSFERASE-TRANSFERASE INHIBITOR complex