Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)

Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Phosphatidylinositol 3-kinase regulatory subunit alpha

PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta

PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha

U VALUES : WITH TLS ADDED HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (E.C.2.7.1.153), Phosphatidylinositol 3-kinase regulatory subunit alpha

PI3Kdelta kinase, transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex