Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin

Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.

0.1 M citric acid; 0.8 M ammonium sulfate; pH 5.0

Anti-kappa antibody is a crystallization aid, not required for the KoH Fab binding to marinobufagenin.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED

KoH body Fab heavy chain, KoH body Fab light chain, anti-kappa antibody Fab heavy chain, anti-kappa antibody Fab light chain

Marinobufagenin, antibody engineering, Bence-Jones dimer, IMMUNE SYSTEM