Crystal structure of procaspase-8 in complex with covalent small molecule inhibitor 63-R

Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity.

CASP-8,Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH

0.1 M imidazole, pH 8.0, 1.0 M sodium citrate

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Department of Energy (DOE, United States)

zymogen, procaspase, covalent inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex

binding site for Di-peptide 63R B 600 and CYS B 360