The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.

25% PEG3350, 0.1 M Ammonium Sulphate and 0.1 M Bis-Tris, 2.5 mM dcAdoMet, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 288K

The crystal structure of spermidine synthase from p. falciparum in complex with 5'-methylthioadenosine

The crystal structure of spermidine synthase from p. falciparum in complex with AdoDATO

The crystal structure of spermidine synthase from p. falciparum in its apo form

The biological unit is a dimer (chains B & C)

TRANSFERASE, SPERMIDINE SYNTHASE, STRUCTURAL GENOMICS CONSORTIUM, SGC, dcAdoMet complex