Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.

50 mM NaAcetate, 100 mM NH4 SO4 , and 20% PEG4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K

N-alpha acetylated form of histone H3 (synthetic)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

WD repeat-containing protein 5, N-alpha acetylated form of histone H3

chromatin, histone, beta-propeller, scaffolding, RbBP5, MLL1, nucleus, TRANSCRIPTION - TRANSCRIPTION INHIBITOR complex, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex

BINDING SITE FOR CHAIN C OF N-ALPHA ACETYLATED FORM OF HISTONE H3

BINDING SITE FOR CHAIN D OF N-ALPHA ACETYLATED FORM OF HISTONE H3