Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344

TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.

Crystal Logic diffractometer consisting of a mini-kappa goniometer

20% PEG 3350, 0.2M MgCl2, 0.1M Hepes pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 300K

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033

MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1', P1' GROUP, Calcium, Collagen degradation, Disease mutation, Extracellular matrix, Glycoprotein, Metal-binding, Polymorphism, Secreted, Zymogen