Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid

[2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid

Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.

Well solution 16 % PEG monomethyl ether 5000, 0.1 M Bis-Tris

Drop ratio 1:1 enzyme mix/ well solution

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Inhibitor, TS, TRANSFERASE, transferase-transferase inhibitor complex