Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

Hydroxymethylglutaryl-CoA synthase, cytoplasmic

HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase

0.2M (NH4)2SO4, 0.1M Bis-Tris pH 6.5, 25% PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 297K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Hydroxymethylglutaryl-CoA synthase, cytoplasmic (E.C.2.3.3.10)

hydromethylglutaryl CoA, mevalonate pathway, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE