Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.

(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl methylcarbamate

Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.

PEG 8000, ammonium sulfate, sodium acetate

4P6E contains an inhibitor of similar scaffold.

cathespsin S, non-covalent inhibitor, cysteine protease, HYDROLASE-HYDROLASE INHIBITOR complex